There is a sex disparity in multiple cancers throughout the human bo dy where males have higher incidence and mortality compared to females. Dat a are emerging that implicate the effects of biological sex as an important driver of this disparity. While some of the sex differences that explain t his disparity come from the actions of sex hormones\, Dr. Ippolito’s lab is discovering cell-intrinsic sex differences in cellular metabolism where ma le cancer cells have higher consumption of sugars and amino acids compared to females. We demonstrate that this phenomenon can be used to predict sex- specific response as well as resistance to conventional cancer therapies. T ogether\, these findings highlight a new paradigm in precision oncology tha t focus on sex and metabolism to improve outcomes.
CATEGORIES:University of Missouri LOCATION:NextGen Precision Health Building GEO:38.938639;-92.324918 ORGANIZER;CN="McKinzie":MAILTO:tolliver.m@wustl.edu URL;VALUE=URI:https://icts.wustl.edu/events/event/nextgen-precision-health- ellis-fischel-cancer-center-science-seminar-5/ END:VEVENT BEGIN:VTIMEZONE TZID:America/Chicago BEGIN:STANDARD TZOFFSETFROM:-0500 TZOFFSETTO:-0600 DTSTART:20221106T070000 TZNAME:CST END:STANDARD END:VTIMEZONE END:VCALENDAR