Clinical & Translational Imaging Unit (formerly the Human Imaging Unit)

The Clinical & Translational Imaging Unit (CTIU) - a component of the Clinical Research Nucleus (CRN) - consists of three Research Imaging Facilities in the Department of Radiology – the Center for Clinical Imaging Research (CCIR), the Radiology Clinical Research Core (RadCore), and the Cyclotron Facility.

The CCIR is a state-of-the-art biomedical imaging facility located on the 10th floor of the West Pavilion of Barnes-Jewish Hospital in St. Louis, MO. The CCIR provides the latest in advanced imaging technology, equipment and expertise to support basic and translational inpatient and outpatient clinical research.

RadCore provides coordination and project management services to support the basic and clinical research of Washington University investigators. RadCore assists in the training, design, execution, financial management, and analysis of basic and clinical research.

The Mallinckrodt Institute of Radiology (MIR) at the Washington University School of Medicine (WUSM) Cyclotron Facility and Nuclear Pharmacy provides positron emission tomography (PET) isotopes, radiochemicals, radiotracers and radiopharmaceuticals to the research and medical communities. Used for research and clinical practice, these agents meet or exceed user requirements, while safely and reliably insuring the highest level of quality that is achievable within federal regulations and guidelines.

Services & Resources

CTIU provides a full range of biomedical imaging, study coordination, and radiopharmaceutical services
These services include:

CCIR Facilities

  • Subject waiting area
  • Two consultation rooms
  • Nurses’ workstation
  • Locked supply storage area
  • Temporary storage area
  • Refrigerator
  • Lab resources (not including supplies)
  • Wireless capability for laptops
  • Conference room
  • Technical expert staff for consultation and protocol integration
  • Assistance from nurses, coordinators and technologists
  • HPLC
  • Blood Sampler
  • Gamma Counter
  • Small Centrifuges
  • Hot labs

RadCore Services

  • Grant/protocol development
  • IRB/FDA Preparation, Submission, and Management
  • Budget Preparation and Negotiations
  • Contract Execution
  • Protocol Training and Study Start Up
  • Subject Recruitment and Enrollment
  • Study Coordination and Data Collection
  • Image Processing and Uploading
  • Study Termination

Cyclotron Facilities

  • Radiopharmaceuticals: Portfolio of over 20 human-use radiopharmaceuticals
  • Radiopharmaceutical development: Translation from bench to human use
  • Pharmacy services: Aseptic training, RDRC submission and writing of INDs, etc

Personnel Support

The CTIU has access to personnel with a wide range of expertise. The RadCore has 5 Sr. Clinical Research Coordinators, a Regulatory Specialist, and a Billing and Data Specialist. In addition, the CCIR has established a formal master research agreement with Siemens Medical which provides full-time, on-site personnel that work with WUSM to promote the development of new biomedical imaging technologies. The Cyclotron Facility provides a dedicated staff of scientists and pharmacists to ensure that both standardized and research offerings are handled with little need of outside assistance. The Cyclotron Facility can also help to develop new product offerings along with oversight into the regulatory requirements for these new products.

These groups work together to provide services, support, maintenance, and development needs for the Center.

Equipment

The CTIU has access to five state-of-the-art imaging scanners used to conduct research, this includes two 3T magnetic resonance imaging scanners (MRI), a Prisma and Vida, two combined PET/CT scanners a Vision and Biograph 40, and a combined PET/MRI.

The Cyclotron Facility operates four cyclotrons housed in two separate locations on the WUSM campus which are capable of producing short-lived and longer-lived isotopes that can be used for a variety of imaging protocols. To utilize the material that is produced by each cyclotron, the facility has been outfitted with state of the art production, processing and distribution equipment capable of safely providing the necessary radioactive drug products.

Bioimaging Scanners

Scanner

Modality

Vida

3T MRI Scanner

Biograph 40

PET/CT

Vision

PET/CT

Prisma

3T MRI Scanner

Biograph mMR

PET/MR Scanner

Facilities & Other Resources

For a description of the CTIU and other ICTS resources, see the Tools and Resources page.

Affiliations

Clinical Research Nucleus (CRN)

Clinical Research Laboratory (CRL)