“Young people with this protective variant in the alcohol dehydrogenase gene, ADH1B, had a lower risk of becoming intoxicated and developing early symptoms of alcohol use disorder,” said first author Emily Olfson, an MD/PhD student doing research in the Department of Psychiatry. “But when in a high-risk environment — that is, if they reported that ‘most or all’ of their best friends drank alcohol — the gene’s protective effect essentially disappeared. Read more.