Aubrey R. Morrison, MD

Professor of Medicine

Washington University in St. Louis (WU)

The focus of the laboratory is directed at understanding the role of RNA-binding proteins which stabilize and/or de-stabilize unstable mRNA e.g. COX-2 mRNA and to determine their roles in colon cancer biology. Specifically we focus on understanding the mechanism(s) of the constitutive expression of COX-2 in colon cancers and the role of the RNA-binding proteins, HuR, TIA-1/TIAR and AUF-1.