Bruno A. Benitez, MD

Assistant Professor

Washington University in St. Louis (WU)

I am a physician-scientist studying the functional consequences of disease-causing and risk-associated variants in Alzheimer’s disease (AD), Parkinson’s disease (PD), and adult-onset Neuronal ceroid lipofuscinosis (ANCL). As part of my research projects, I use a combination of state-of-the-art approaches in human genetic discoveries (e.g. whole-exome sequencing and GWAS data), functional genomic analyses (e.g. single nuclei RNA-sequencing) with in vitro (e.g. patient-derived iPS cells), and in vivo (e.g. stereotaxic delivery of Adeno-associated virus (AAV) or alpha-Synuclein preformed fibrils in AD or PD mouse models) experiments.