Duane P. Grandgenett, MS, PhD

Professor of Molecular Virology

Saint Louis University (SLU)

Integration of HIV-1 and other retrovirus DNA genomes by the viral integrase into host chromosomes is essential for virus replication. We use biochemical and structural approaches including Cryo-EM and X-ray crystallography to investigate the functional mechanisms associated with Rous sarcoma virus and HIV-1 integrases and, with HIV-1 integrase inhibitors. HIV-1 integrase is a significant clinical target for FDA approved strand transfer inhibitors.