Eugene Oltz, PhD

Professor of Pathology and Immunology

Washington University in St. Louis (WU)

The packaging of DNA in the nucleus is a key determinant of gene function; changes in these “epigenetic” programs are likely to be at the heart of many diseases. We propose studies to characterize the epigenome of lymphocytes in patients suffering from a common form of non-Hodgkin Lymphoma, with the goal of establishing tumor-specific epigenetic signatures. The signatures will then be targeted for a novel therapy in which abnormal epigenetic patterns are reversed specifically at regions in the genome that control the inappropriate expression of lymphoma genes.