Gavin P. Dunn, MD, PhD

Associate Professor of Neurological Surgery

Washington University in St. Louis (WU)

Whereas extensive genomic profiling is uncovering tumor cell vulnerabilities across many cancer types, this paradigm has not extended to glioblastoma due, at least in part, to the tremendous heterogeneity within these tumors. In contrast to conventional targeted therapeutic approaches, immune-based strategies may be particularly well-suited to treating these tumors due to the incredible diversity of antigens recognizable by immune cells. My laboratory is focused on understanding the molecular and cellular basis of the immune response to glioblastoma in preclinical and translational settings as well as clarifying the relationships between glioma genomics and immunogenicity, an area termed “cancer immunogenomics.” These investigations are complemented by ongoing clinical trial efforts in this area.