University of Missouri – Columbia (MU)
My area of research is the regulation of mitochondrial dynamics, including fission/fusion, movement, metabolism, cell death signaling and mitophagy. My laboratory has identified a novel protein phosphatase, PGAM5 and characterized both its biochemical activity and its cellular function in regulation of mitochondrial dynamics. We are particularly interested in the identification of small molecules that modulate the phosphatase activity of PGAM5.