Philip C. Spinella, MD

Associate Professor of Pediatrics

Washington University in St. Louis (WU)

Research areas of interest include the clinical effects of the storage lesion of red blood cells and platelets, the use of functional coagulation monitoring to improve the efficacy of blood component transfusions and reduce the risk of severe thrombotic events in critical illness, and optimizing transfusion strategies and outcomes for patients in hemorrhagic shock. Storage lesion mechanisms that are being explored include the dysregulation of immune, coagulation, and endothelial function with the transfusion of blood products of increased storage age in critically ill patients.