Walter A. Boyle, MD

Professor of Anesthesiology

Washington University in St. Louis (WU)

The laboratory has two main interests. The first concerns mechanisms of vascular failure in septic shock. Ongoing studies, utilizing isolated micro-vessels and intact animal models, are directed at the identification and use of specific inhibitors for the phosphatase which degrades phosphorylated myosin as a potential therapeutic strategy to reverse the excessive vasodilation and catecholamine resistance that occur in this condition. The second focus is identification of novel biomarkers of organ injury in the urine proteome. Ongoing studies utilizing immunoassay and mass spectrometric techniques, being conducted in critically ill patients with myocardial injury and patients undergoing a timed myocardial infarction (percutaneous transluminal septal myocardial ablation for hypertrophic obstructive cardiomyopathy), are directed at the discovery of urinary biomarkers that can be used to identify and follow acute cardiac injury non-invasively.