Zhongping Xu, PhD

Postdoc Research Associate

Washington University in St. Louis (WU)

Despite this improvement in early survival, the longterm outlook for lung allograft recipients is bleak due to a syndrome of chronic lung allograft dysfunction termed bronchiolitis obliterans syndrome (BOS). Although much has been written on the possible etiologic factors involved in the pathogenesis of BOS, to date there are no definitive answers to explain the basic mechanisms leading to the development of BOS. However, it is widely presumed that this condition is due to chronic rejection. The findings of significant correlation between the development of anti-HLA antibodies (Abs) during the post-transplant period and development of BOS in lung transplant recipients support this hypothesis. Our research focus on the role of donor specific anti-HLA and anti-endothelial Abs in the development of BOS after LTx. The kinetics of post-transplant development of Abs specific for donor HLA and endothelial antigens will be prospectively analyzed by cytotoxicity and immunofluorescence methods.