Please join us for the 6th annual symposium hosted by the Institute of Clinical and Translational Sciences.

Keynote Speaker

Dr. Ruth O’Hara is\, unfortunately\, unable to provide the keynote address. We hope to reschedul e her presentation for a future date and will contact symposium registrants with this information when available.

Agenda< /span>

< td>8:30 am

Attendee check-in
9:00–9:30 am	Welcome by ICTS Director William Powderly\, MD *ICTS Update and Future D irections* Dr. Powderly will highlight ICTS achievements and discuss future initiatives as the ICTS embarks upon its 17^th year of consecutive funding from the National Center for Advancing Transl ational Sciences. Winners of the poster competition will be announced.
9:30-10:15 am	Research Panel: Addressing the Gap betwe en Early-phase Research and Clinical Trials Panelists: Kory Lavine\, MD\, PhD\; Professor of Med icine (Cardiology)\, Developmental Biology\, Pathology and Immunology < li>Rachel Presti\, MD\, PhD\; Profe ssor of Medicine (Infectious Diseases) Christina Stallings\, PhD\; Professor of Molecular Microbio logy Fumihiko Urano\, MD\, PhD\; Professor of Medicine (Endocrinology)\, Pathology and Immunology Moderated by Christina Gurnett\, MD\, PhD
10:15–11:4 5 am	Addressing the Gap Between Clinical Trials and Implementation into Clinical Practice and Population Health Presenters will each add ress a facet of research in the T3/T4 stage of translational science and th en convene for a panel immediately following at 11:00 am. Presenters/ Panelists: Brett Maricque\, PhD\; Assistant Professor of Genetics\; “Towards Greater Equity in Genom ics: A Community-Engaged Approach” Laura Marks\, MD\, PhD\; Assistant Professor of Medicine (Inf ectious Diseases)\; “From Garbage to Knowledge: Leveraging Basic Scienc e to Inform Clinical Care for People who Inject Drugs” Nandini Raghuraman\, MD\, MSCI\; Assistant P rofessor of Obstetrics and Gynecology\; “De-Implementation of Low-Value Care” Moderated by William Powderly\, MD
11:45 – 12:30 pm	Boxed lunches available. Poster award recipients available with their posters in lobby.

Speakers

Research Panelists

Kory Lavine\, MD\, PhD
Profe ssor\, Medicine\, Cardiovascular Division
Professor\, Developmental Bi ology\, Pathology\, and Immunology
Director\, Center for Cardiovascula r Research
Washington University School of Medicine

Lavine is th e Alan and Edith Wolff Professor in Cardiology\, Director of the Center for Cardiovascular Research at Washington University School of Medicine\, and a practicing\, board-certified cardiologist with expertise in advanced hear t failure and cardiac transplantation. He is also the principal investigato r of a basic and translational science laboratory focused on understanding the importance and therapeutic implications of immune cell diversity in car diovascular diseases. Lavine received his bachelor’s degree in biological s ciences at the University of Rochester and completed his medical and scient ific training at WashU\, including a fellowship in advanced heart failure a nd transplant. He has been the recipient of numerous awards and is an elect ed member of the American Society of Clinical Investigation.

Rachel Presti\, M D\, PhD\, FIDSA
Professor\, Medicine\, Infectious Disease
Virology Section Head
Director\, Infectious Disease Clinical Res earch Unit
Washington University School of Medicine

Presti is a Professor of Medicine and Section Head for Virology in the Division of Infe ctious Disease at Washington University. Her research interests center arou nd the pathogenesis of infectious diseases\, with a particular emphasis on the immunologic response and pathogenesis of viral infections\, particularl y HIV and other emerging viruses. Since 2006\, she has conducted clinical t rials at the Washington University Infectious Disease Clinical Research Uni t\, where she is medical director and PI of the AIDS Clinical Trials Group (ACTG). She has conducted groundbreaking research in HIV through ACTG and i ndependently funded trials. Dr. Presti responded aggressively to the COVID- 19 pandemic\, conducting translational research to understand immune respon ses after infection or vaccination as well as treatment\, prevention\, and vaccination trials for SARS-CoV-2.

Christina Stallings\, PhD
Professor\, Department of Mo lecular Microbiology
Center for Women’s Infectious Disease Research (c WIDR)
Co-Director\, Molecular Microbiology and Microbial Pathogenesis Graduate Program
Washington University School of Medicine

Stalli ngs is a Professor in the Department of Molecular Microbiology and the Cent er for Women’s Infectious Disease Research. She serves as the Co-Director o f the Molecular Microbiology and Microbial Pathogenesis Graduate Program at Washington University and is a Co-Founder of the Philip and Sima Needleman Center for Autophagy Therapeutics and Research. She started her faculty po sition at Washington University School of Medicine in 2010 and research in her laboratory seeks to dissect the molecular mechanisms involved in Mycoba cterium tuberculosis pathogenesis while also translating her basic science findings to the development of new therapeutics to treat bacterial infectio ns.

Fumihiko Urano\, MD\, PhD
Professor of Medicine\, Pathology\, and Immunology
Division of Endoc rinology\, Metabolism & Lipid Research
Director\, Wolfram Syndrome Int ernational Registry & Clinical Study
Washington University School of M edicine

Urano is a physician and medical researcher specializing in W olfram syndrome\, characterized by juvenile-onset diabetes\, vision loss\, hearing loss\, and neurodegeneration. He is a Professor of Medicine and Pat hology & Immunology\, an attending physician at the Endocrinology Genetics Clinic\, and currently holds a Samuel E. Schechter Endowed Professorship in Medicine at Washington University in St. Louis. As the Director of the Wol fram Syndrome and Related Disorders Clinic and Study at Washington Universi ty Medical Center\, he is a driving force and has been leading the basic sc ience\, clinical\, translational\, and interventional studies of Wolfram sy ndrome and related disorders. Urano’s collaboration with colleagues at the medical center and around the world has allowed him to develop innovative t reatments for this disease\, including gene therapy and regenerative therap y.

Presenters

Brett Maricqu e\, PhD
Assistant Professor of Genetics
Co-Director\ , Center for Community Health Partnership & Research
Washington Univer sity School of Medicine

Maricque is an Assistant Professor of Genetic s at Washington University School of Medicine (WUSM) and a faculty member a t the McDonnell Genome Institute\, where he leads the Black Genome Project. He also co-directs the Center for Community Health Partnership & Research and works on healthcare access and delivery using human-centered design. Pr ior to joining the WUSM faculty\, he was the Coordinating Manager of Young Adult Services at NYC Health + Hospital Correctional Health Services\, wher e he coordinated mental and physical health services and delivered project- based education programs to adolescents and young adults who were incarcera ted in New York City’s jails. Maricque teaches genomics and data science in WashU’s prison education program.

Laura Marks\, MD\, PhD< /strong>
Assistant Professor of Medicine\, Division of Infectious Dise ases
Washington University School of Medicine

Marks is an Assist ant Professor in the Division of Infectious Disease at Washington Universit y in St. Louis\, MO\, where she also serves as the medical director of the Bridge to Health Program\, which is an interdisciplinary clinic that provid es care for patients with infectious complications of substance use disorde rs. Her research focuses on S. aureus infections in people who inject drugs \, and her group uses a combination of clinical epidemiology\, translationa l\, and laboratory approaches. She attends on the general infectious diseas es consult service\, teaching fellows\, residents\, and students.

Nandini Raghuraman\, MD\, MSCIAssistant Professor\, Division of Maternal-Fetal Medicine
Chief of the Division of Clinical Research\, Department of Obstetrics and Gynecolog y
Maternal-Fetal Medicine Fellowship Program Director
Washington University School of Medicine

Raghuraman is a board-certified Materna l-Fetal Medicine specialist and physician-scientist in the Department of Ob stetrics and Gynecology. She has research expertise in obstetric randomized trials\, labor and delivery interventions\, and implementation of evidence -based labor management. She has several ongoing NIH and foundation-funded prospective studies and randomized trials investigating intrapartum interve ntions and response to fetal monitoring to optimize maternal and neonatal m orbidity at the time of delivery. She is also the site PI for multicenter r andomized trials investigating interventions for high-risk conditions in pr egnancy\, such as anemia and hypertension. She has authored over 90 manuscr ipts related to clinical obstetrics and high-risk pregnancy management and serves as an Associate Editor for the American Journal of Obstetrics and Gy necology.

Moderators

Christina Gurnett\, MD\, PhD
A. Ernest and Jane G Stein Professor of Neurology
Head\, Divi sion of Pediatric and Developmental Neurology
Chief of Neurology\, St Louis Children’s Hospital
Co-Director\, Intellectual and Developmental Disabilities Research Center
Associate Director\, Institute of Clinic al and Translational Sciences
Washington University School of Medicine

Gurnett is the A. Ernest and Jane G Stein Professor of Neurology and Head of the Division of Pediatric and Developmental Neurology at Washingto n University in St Louis\, and the Chief of Neurology at St Louis Children’ s Hospital. She has an active neurogenetics research program focused on gen e discovery for pediatric musculoskeletal disorders\, which has resulted in identifying new genes for clubfoot\, arthrogryposis\, and scoliosis. She a lso co-directs the Precision Medicine Pathway for graduate students and is strongly committed to training a diverse workforce in her clinical division and research laboratory. During the COVID-19 pandemic\, Gurnett has facili tated the distribution of biospecimens to researchers from patients with SA RS-CoV-2\, which supported Washington University’s development of the saliv a-based test for SARS-CoV-2 at GTAC@MGI.

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$William Powderl y\, MD$

Wil liam Powderly\, MD
J. William Campbell Professor of Medic ine
Associate Dean for Clinical and Translational Sciences
Direct or\, Institute of Clinical and Translational Sciences
Larry J. Shapiro Director\, Institute for Public Health
Co-Director of the Division of Infectious Diseases
Washington University School of Medicine

Po wderly is the Dr. J. William Campbell Professor of Medicine and co-Director of the Division of Infectious Diseases. He is also the Larry J Shapiro Dir ector of the Institute for Public Health\, Associate Dean for Clinical and Translational Science\, and Director of the Institute of Clinical and Trans lational Sciences at Washington University. Powderly has been actively invo lved in HIV-related clinical research for over thirty years with specific i nterests in opportunistic infections\, metabolic complications\, and long-t erm outcomes of antiretroviral therapy. His major recent focus is translati ng scientific advances to a wider population to improve public health. He a ttends on the ID consult service teaching fellows\, residents\, and student s. He is the author of over 400 original manuscripts\, reviews\, and book c hapters.

S ponsors