5. Antigen-guided Depletion of Anti-HLA Antibody-producing Cells by HLA-Fc Fusion Proteins

Introduction: Platelet transfusion and transplantation of allogeneic stem cells and solid organs are life-saving therapies. Unwanted alloantibodies to non-self human leukocyte antigens (HLA) on donor cells increase the immunological barrier to these therapies and are important causes of platelet transfusion refractoriness and graft rejection. Although the specificities of anti-HLA antibodies can be determined at the […]