8. Evolution of a Functionally Intact but Antigenically Distinct Dengue Virus Fusion Loop

Introduction: A hallmark of Dengue virus (DENV) pathogenesis is the potential for antibody dependent enhancement (ADE), which is associated with deadly DENV secondary infection, complicates the identification of correlates of protection, and negatively impacts the safety and efficacy of DENV vaccines. ADE is linked to antibodies targeting the pre-Membrane (prM) protein and the fusion loop […]