Directors' Message

Dr. Gurnett

William G. Powderly, MD
Director, Institute of Clinical and Translational Sciences
J. William Campbell Professor of Medicine & Co-director, Infectious Diseases Division
Larry J. Shapiro Director, Institute of Public Health

Christina A. Gurnett, MD, PhD
Associate Director, Institute of Clinical and Translational Sciences
Professor, Departments of Neurology, Pediatrics and Orthopaedic Surgery

Welcome to the Washington University Institute of Clinical and Translational Sciences (ICTS). The Institute was established in 2007 through a Clinical and Translational Science Award (CTSA) from the National Institutes of Health, as well as institutional support from Washington University and BJC HealthCare. The programs and services of the ICTS are designed to speed the translation of research findings into their application to improve prevention, diagnosis, and treatment. The ICTS is a catalyst for intra- and inter-institutional cooperation and collaboration at Washington University (WU) its partnering health care system BJC Healthcare, and our academic partners Saint Louis University (SLU), the St. Louis College of Pharmacy (STLCOP), and the University of Missouri-Columbia (MU). These are other partnerships with academic, health care, and community organizations support the ICTS mission and the overarching goals of the national CTSA consortium.

The ICTS has always been an ambitious undertaking: we are tasked by the NIH with transforming research and research training in order to accelerate the translation of new scientific findings into health practice. Since its inception, the ICTS has made tremendous strides toward achieving its original aims:

  • Provided the infrastructure, resources and services needed to stimulate and facilitate the performance of outstanding, safe and ethical interdisciplinary research
    • Funded over 186 pilot awards leading to over $134.5M in external awards and more than 342 publications.
    • Provided core services acknowledged in over 2554 scientific publications, and annually evaluate the productivity, collaboration, and impact of scholarly work supported by the ICTS.
  • Created a centralized home for Clinical and Translational Research Training (CRTC) and Career Development Programs for multiple disciplines
    • To date, the CRTC has established 38 new courses and several training programs.
    • Awarded 174 Master of Science in Clinical Investigation degrees.
    • 165 MTPCI (Mentored Training Program in Clinical Investigation) have over 3700 published manuscripts and nearly 480 external awards.
    • Graduated 60 KL2 scholars who have published over 1500 manuscripts; to date, 78% of KL2 alumni have received independent funding.
  • Established inter-institutional partnerships for clinical research and training with community, academic health care, and industrial organizations regionally and nationally
    • Established regional partnerships supporting inter-institutional research collaborations.
    • Established cross-CTSA funding programs (SPIRiT and SPARC) to promote collaboration at the CTSA consortium level.

New ICTS functions and components are meant to enable our members to continue and to extend our past successes in clinical and translational research.  Several newer areas of focus have been introduced in order to promote our cross cutting themes, including: 1) a Translational Genomics function which will speed incorporation of clinical genomics into health care; 2) our Implementation Science and Entrepreneurship Module that will leverage the untapped synergy between these two highly complementary fields to increase the ability of translational researchers to develop effective, scalable, and sustainable interventions and products that are effectively implemented to improve human health; and 3) an emphasis on clinical trials, especially multicenter trials, through the establishment of innovative services to streamline our investigators' ability to recruit research participants from diverse populations,  use a central Institutional Review Board and master trial agreements, receive regulatory guidance services, and work with partner organizations in the CTSA network.

A simple ICTS Membership Registration process allows members from WU and our partner institutions to discover and gain access to diverse resources and an opportunity to identify local research mentors and collaborators. Simple access to ICTS services and cores is provided through this website, through assistance from the ICTS Research Navigator (ICTS or Administrative Core, or personal contact with any of the individual Program Directors.

Please register as a member and join us in this exciting ongoing endeavor.