Hope Center Cores

The Hope Center Cores Provide investigators with core resources and technical expertise to study mechanisms of neurodegeneration and repair.  These include state of the art neuroimaging, animal surgery combined with microdialysis, transgenic and viral vector design and high-throughput screening.  

Core Services:

  • Alafi Neuroimaging Core: offers state-of-the-art equipment and software for imaging and scanning for application in translational studies. Contact Core Director, Michael Wong (wongm@neuro.wustl.edu).

  • Animal Surgery Core: facilitates the development of new therapeutic strategies for nervous system disorders through expertise in animal surgery and/or protocol development.  Contact Karen Smith (smithkp@wustl.edu).

  • DNA/RNA Purification Core: offers nucleic acid extraction from a variety of sources including fresh or frozen whole blood, buffy coat, saliva and frozen tissue and cell pellets.  Large and small volume extractions are available. Contact Carlos Cruchaga (cruchagac@wustl.edu).

  • In vivo microdialysis: sampling of molecules within the extracellular tissue space (brain and muscle) to identify compounds for their ability to reduce brain interstitial fluid levels of Ab or other analytes. Contact Core Director, John Cirrito (cirritoj@neuro.wustl.edu).

  • Transgenic Vectors Core: offers support for the design and construction TALENs, CRISPR/Cas9 and gene targeting vectors for genome modification in a variety of organisms and cell types. Contact Renate Lewis (lewisr@neuro.wustl.edu).

  • Viral Vectors Core: provides core support for investigators on the design and construction lentiviral and AAV vectors and other services for neuroscience applications. Contact Mingjie Li (lim@neuro.wustl.edu).

  • Microelectrode Array (MEA) Device System:  The Maestro microelectrode array (MEA) system [Axion Biosystems] supports investigators interested in high-throughput screening of drug effects on excitability, disease-in-a-dish modeling, and other applications for dissociated cultures of excitable cells (e.g., rodent neurons, human induced neurons, cardiac myocytes, and smooth muscle cells). Contact GENETICS-tissueculturecenter@email.wustl.edu or Anneliese Schaefer (amschaefer@wustl.edu)

Contact: To learn more about Hope Center Core services, please contact Anneliese Schaefer, amschaefer@wustl.edu; 314.747.3429.