Washington University in St. Louis (WU)
Accurate DNA replication is essential to prevent the occurrence of mutations and chromosome rearrangements associated with several cancer related pathologies. Our group studies the mechanisms that operate in eukaryotic cells to maintain replication fork integrity with particular emphasis on the role of RecQ helicases in this process. Owing to the fast proliferative properties of cancer cells, many DNA replication inhibitors are currently used as anticancer agents. Our studies provide new mechanistic insight into the role of RecQ helicases in replication stress response offering new molecular perspectives to potentiate chemotherapeutic regimens based on replication inhibitor treatment.