Anutosh Chakraborty, PhD
Saint Louis University (SLU)
My laboratory deciphers impacts of novel biomolecules in cell signaling, metabolism and survival. I have extensive experience in small molecule and protein kinases. A major focus is to determine the in vivo significance of the inositol pyrophosphate IP7 (Chakraborty A. Biol. Rev. 2017). We discovered that mice deleted or inhibited of the major IP7 synthesizing enzyme IP6K1, are protected from diet induced obesity (DIO), fatty liver and insulin resistance. We work on the development of efficacious IP6K1 inhibitors to treat obesity and associated diseases.
A complete understanding of the various cellular processes is critical to design and develop therapeutic strategies against diseases. We identified a number of proteins that are altered in various cellular conditions or in diseases, although their roles and regulations are unknown. The long-term goal of the laboratory is to elucidate functions of these proteins, with a hope that one/few would emerge as novel therapeutic targets.