Brian P. Downes, PhD

Saint Louis University (SLU)

Many diseases arise when proteins are not accurately modified with the small protein tag ubiquitin (Ub). The mechanistic catalog of Ub driven cell biology and physiology continues to grow in surprising ways yielding new opportunities to develop medicinal interventions. Our lab unveils such non-canonical Ub reactions in order to more fully harness the potential of the Ub system for human health.