Washington University in St. Louis (WU)
Type I interferons are a class of cytokines that regulate numerous biological pathways, including the induction of a host antiviral state, regulation of apoptosis, inhibition of cell growth, and modulation of both the innate and adaptive immune responses. Interferons mediate these activities through the induction of hundred of gene products known as interferon stimulated genes (ISGs). We are interested in identifying novel ISGs that function to modulate the host anti-viral response, the innate and adaptive immune response, and their role in the development of autoimmunity.