Dolores B. Njoku, MD

Division Chief, Pediatric Anesthesiology, Vice-Chair Anesthesiology

Washington University in St. Louis (WU)

My laboratory investigates the basis of sex differences in drug-induced, immune-mediated, liver disease as well as metabolic liver diseases in humans and mice using a novel model of drug-induced steatohepatitis, a rare form of non-alcoholic steatohepatitis. My lab has ascertained regulators of sex differences in immune-mediated, liver diseases, which have included, CD4+T cells, CD1d+B cells, FoxP3+CD4+regulator T cells, as well as cytokine and molecular modulators of these cells. More recently we have extended our investigations of sex differences in immune-mediated, liver disease to include extra-hepatic manifestations of disease. It is our intent to identify modifiable mechanisms that remediate intra and extra-hepatic manifestations of immune-mediated liver disease in patients.