Dolores B. Njoku, MD

Wise Endowed Chair in Pediatric Anesthesiology, Vice chair department of Anesthesiology

Washington University in St. Louis (WU)

My laboratory investigates the basis of sex differences in drug-induced, immune-mediated, liver disease as well as metabolic liver diseases in humans and mice using a novel model of drug-induced steatohepatitis, a rare form of non-alcoholic steatohepatitis. My lab has ascertained regulators of sex differences in immune-mediated, liver diseases, which have included, CD4+T cells, CD1d+B cells, FoxP3+CD4+regulator T cells, as well as cytokine and molecular modulators of these cells. More recently we have extended our investigations of sex differences in immune-mediated, liver disease to include extra-hepatic manifestations of disease. It is our intent to identify modifiable mechanisms that remediate intra and extra-hepatic manifestations of immune-mediated liver disease in patients.