Hannah M. Phelps, MD
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Washington University in St. Louis (WU)
Short gut syndrome (SGS) results from massive small bowel resection (SBR), which may be required to treat a variety of conditions. In children, the most common indications for massive SBR and resultant SGS include neonatal necrotizing enterocolitis, congenital intestinal atresia, and midgut volvulus. Parenteral nutrition (PN) has made survival beyond infancy possible, but the overall mortality from SGS remains approximately 25%. Those who do survive are at risk for severe metabolic, renal, and hepatobiliary complications. Despite profound morbidity, mortality, and economic burden associated with SGS, it remains a clinically understudied entity. The overarching goal of my research is to understand the contribution of key pathways to the genesis of SGS-associated liver injury, fibrosis, and ultimately end-stage liver disease.