Jinbin Xu, MS, PhD

Washington University in St. Louis (WU)

Extensively experienced in the biomedical imaging science, with a focus on the development and characterization of probes for receptor and enzyme-based central nervous system (CNS) and oncology imaging using in vivo Positron Emission Tomography (PET) and in vitro quantitative autoradiography. Dr. Xu is an expert in postmortem rodent/nonhuman primate/human brain quantitative autoradiography and high throughput receptor-ligand binding assays. Dr. Xu developed a novel autoradiography procedure for measuring dopamine D2 and D3 receptor density ratios. This method has been effectively used both with animal models of neurological disease and for human postmortem brain autoradiography. He also played a key role in the validation of the sigma-2 receptor as an imaging biomarker for cell proliferation, and in the development of sigma-2 receptor antagonists against amyloid-beta oligomer toxicity in human neurons as a therapeutic agent in Alzheimer’s disease.