Washington University in St. Louis (WU)
My lab investigates liver macrophage dysfunction in obesity/diabetes and heart failure. In particular, we have been dissecting the role of resident and recruited myeloid cells in the liver during the development of non-alcoholic fatty liver disease using a variety of in vivo and ex vivo approaches. We are taking similar approaches to dissect the changes in macrophage composition and function that occur with right heart failure. From a translational perspective we have also been working with human liver samples and blood samples from subjects with metabolic liver disease and heart failure to translate our findings to patients.