Joshua S. Siegel, MD, PhD


Washington University in St. Louis (WU)

My research focuses on how psychopharmacological agents (particularly experimental therapies for depression) work. The neural correlates of depression are far more complex than a simple “chemical imbalance.” Resting fMRI has enabled us to see that large-scale brain networks are disrupted. The neurotransmitter level and the brain network level of neuroscience offer two related views of depression. But little work has been done to understand that relationship. My focus is on understanding how specific pharmacological interventions alter large scale brain network function.