Katherine Holzem, MD, PhD

Washington University in St. Louis (WU)

My research focus is better understanding of structural remodeling in tibial vascular atherosclerosis. For chronic limb-threatening ischemia, the below-knee (tibial) segment of the peripheral vascular system is our most poorly understood and difficult to treat, and many patients with tibial disease ultimately require amputation. Current methods for restoring blood flow involve adopting strategies from coronary or above-knee revascularization techniques, and the majority of these methods are lack durability in the tibial segment, likely as a result of heavy vessel wall calcification. Ultimately, the ability to treat peripheral vascular disease will require us to have improved understanding of atherosclerotic remodeling and dedicated revascularization strategies for the tibial segment.