Krishna Sharma, PhD

Director of Research

University of Missouri – Columbia (MU)

My lab research interests include investigating the molecular changes associated with lens aging and cataractogenesis. because cataract formation involves aggregation of lens proteins we are interested in understanding protein interactions in the lens and how these interactions are altered during aging or due to different mutation in lens proteins that cause cataract. Maintaining the lens crystallin structure-function is fundamental to maintain lens lens transparency. Therefore, my lab is also interested in developing modulators that will help in maintaining lens transparency. We are also conducting research to expand the application of peptide chaperones to address other diseases involving protein aggregation such as Alzheimer’s, Parkinson etc.