Moe Mahjoub, PhD
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Washington University in St. Louis (WU)
Research in my lab at Washington University focuses on the biology of centrosomes and cilia, the involvement of these essential cellular organelles in development, and their dysfunction in human disease. We have developed innovative in vitro and in vivo systems focused on: (1) identifying regulators of centrosome and cilium assembly, using transgenic mouse strains and ex vivo cell culture systems, and (2) determining the consequences of abnormal centrosome and cilium biogenesis in mammalian development, with specific focus on cystic kidney disease.