Noha N. Salama, PhD

St. Louis College of Pharmacy (STLCOP)

Dr. Salama focuses on pursuing translational (bench- to- bedside) research in the area of pharmacokinetics and applied biopharmaceutics. She examines factors that influence and improve drug delivery across biological membranes via modulation of drug transporters and the tight junctions. Dr. Salama has utilized diverse experimental techniques from the use of in vitro cell culture techniques (e.g. the use of recombinant cell lines), to preclinical animal models to clinical trials. Dr. Salama’s current research projects study the pharmacokinetics and pharmacogenomics of the multidrug resistance protein, P-glycoprotein (P-gp) and the breast cancer resistance protein (BCRP) and evaluating disease associated changes in the overall activity of those drug transporters in special disease populations. The disease emphasis is geared primarily towards systemic inflammatory response (SIRS) and sepsis. In addition to her current research efforts in Critical Care, Dr. Salama is also investigating the pharmacokinetics of drugs (e.g. antibiotics) in renal dysfunction (end stage renal disease patients). These studies are aimed at identifying potential changes in drug dosing in renal disease based on assessments of the extent of dialytic drug removal.