Washington University in St. Louis (WU)
Our laboratory is studying DNA replication and DNA damage response mechanisms in the yeast Saccharomyces cerevisiae and in human cells. Yeast is an ideal eukaryotic organism to study these pathways, both at a genetic and at a biochemical level. It is important to understand these mechanisms in yeast because defects in the highly analogous pathways in humans are known to result in damage susceptibility and show a predisposition to various forms of cancer.