Washington University in St. Louis (WU)
HIV can use one of two co-receptors CCR5 or CXCR4 for for infection and this determines its tropism of activated and resting CD4 T cells respectively. Despite resting CD4 T cells comprising the vast majority of available CD4 T cells for infection, CXCR4 tropic viral infection does not emerge in patients until late in the disease course. We aim to better understand the cell intrinsic and immune components that control X4 viral infection in vivo.