Washington University in St. Louis (WU)
My research area focused on the host’s immune response to Mycobacterium Tuberculosis(Mtb) infection. Mtb cause pulmonary tuberculosis. Currently, I am studying the role of Irgm1 host gene in immune regulation to Mtb infection by using mouse model. Irgm1 is the ortholog gene of IRGM in humans which has been reported to be associated with the outcome of TB disease. TB disease involves different immune cell types that form granuloma in the lungs which is a hallmark of TB. I study the cell-specific role of Irgm1 in different immune cells and try to find the drug therapeutic targets for TB treatment.