William E. Gillanders, MD

Vice Chair for Research, Department of Surgery

Washington University in St. Louis (WU)

Our laboratory is focused on the immunologic intervention to cancer via vaccine development. We are also characterizing the biology of the cell adhesion molecule, EpCAM. EpCAM is overexpressed in breast cancer and this overexpression correlates with poor prognosis. We are interested in the molecular controls that regulate EpCAM expression in breast cancer. Our studies have also identified the role EpCAM has in breast cancer invasion and we are further characterizing the biological signaling of EpCAM in human breast cancer.