Saint Louis University (SLU)
1) Development and implementation of clinical trials to evaluate new drugs and other therapeutic interventions for childhood sarcomas (especially osteosarcoma and Ewing’s sarcoma) and high-risk/relapsed neuroblastoma. Most of these efforts have involved participation in the NCI-sponsored Children’s Oncology Group and the newly formed Neuroblastoma and Medulloblastoma Translational Research Consortium. 2) Expanding the use of umbilical cord blood, both as a therapeutic modality for stem cell transplantation and as part of newly emerging techniques in regenerative medicine. 3) Improving medical care provided for children and young adults with sickle cell disease and other hemoglobinopathies. 4) Ethical and regulatory issues involving the participation of children and adolescents in clinical research trials.