2. Translational Evidence Associating NADPH Oxidase and Heparan Sulfate Proteoglycan Activity with Cerebral Amyloid Angiopathy in Alzheimer Patient Biopsies

Introduction: Most dementia patients have co-existing vascular contributions to cognitive impairment and dementia (VCID). Cerebral amyloid angiopathy (CAA), a form of vascular dementia, bridges the interplay between VCID and Alzheimer’s Disease (AD) pathology and cooccurs in 90% of patients with AD. The hallmark pathology of CAA is characterized by amyloid-ß deposition in cerebrovasculature. Reactive oxidative […]