9. Pathophysiology of Voluntary Motor Commands in People with Multiple Sclerosis Identified Using Reverse Engineering of Motor Unit Population Discharge

Pathophysiology of Voluntary Motor Commands in People with Multiple Sclerosis Identified Using Reverse Engineering of Motor Unit Population Discharge

Introduction: Multiple sclerosis (MS) causes central nervous system lesions that alter neural communication between the brain and the spinal motoneurons that activate muscles. These voluntary motor commands consist of three components that must be appropriately balanced for skilled motor control: excitation, inhibition, and neuromodulation. Disruption of this balance has harmful effects, evidenced by work in […]