Introduction: The mechanisms by which changes in transferrin (TF) saturation regulate hepcidin are unclear. We reported that transgenic mice expressing mutant TF that block iron binding to either N-lobe (N-bl) or C-lobe (C-bl) have differences in erythropoietin sensitivity and hepcidin regulation. To characterize the differential regulation of the gene encoding hepcidin, Hamp1, in these mice […]
7. Lobe Specificity of Iron Binding to Transferrin Differentially Influences the Relationship Between Bone Morphogenetic Protein 6 and Hepcidin Expression in Mice
