16. Pre-infusion Neurofilament Light Chain (NfL) Levels Predict Immune Effector Cell-associated Neurotoxicity Syndrome (ICANS)

Introduction: Neurological side effects after chimeric antigen receptor-modified (CAR) T cell therapy, termed immune effector cell-associated neurotoxicity syndrome (ICANS), are common and potentially devastating. We previously demonstrated that pre-infusion plasma neurofilament light chain (NfL), a well-established marker neurodegeneration, may predict subsequent development of ICANS in a small, single-center cohort. This larger, multicenter study compares pre-infusion […]

17. Effectiveness, Safety, and Tolerability of Different Estradiol Replacement Therapy Presentations in Transgender Females

Introduction: A typical regimen for transgender females includes estrogen to provide feminizing effects in conjunction antiandrogens. There is no data to indicate if a single daily dose vs divided daily doses vs continuous subcutaneous dosing of estradiol is more effective at suppressing endogenous testosterone production. The lack of research on gender affirming hormone therapy represents […]

18. Biological and Chemical Characterization of Aerosols Emitted During Dental Procedures in Real World Settings

Introduction: The composition of real world dental aerosols remained poorly understood. Previous studies have used in vitro experimental designs and/or indirect measures to evaluate bacteria and viruses from dental splatter. However, these findings may overestimate the occupational health risks for dental healthcare personnel (DHCP). The purpose if this study is to directly measure dental aerosol […]

19. Musculoskeletal Impairments Among Women with Urinary Urgency/Frequency

Introduction: Urgency and frequency are common lower urinary tract symptoms (UFLUTS) in women. There is limited evidence to guide physical therapist-led treatment. The focus of this project was to understand how pelvic floor muscle (PFM) strength and endurance, PFM mobility, and hip muscle strength differ between women with and without UFLUTS. Methods: Women with (n=21) […]

20. Coming Up with a COVID (Cure?): Using eConsent and National Recruitment in a Fully-Remote Clinical Trial

Introduction: The STOP COVID Trials were innovative, fully-remote randomized controlled trials of fluvoxamine (a sigma1 receptor agonist with anti-inflammatory properties) vs placebo for treatment of outpatients with early COVID-19 who were self-isolating at home. Methods: The trials used eConsent and an electronic data capture system with integrated recruitment from the Epic electronic health record system. […]

21. Digital Mental Health Intervention for Musculoskeletal Patients with Co-existing Depression and/or Anxiety

Introduction: Although depression and anxiety negatively impact patients’ responses to standard orthopedic treatment, mental health is not routinely addressed in orthopedic care. Digital mental health interventions may be a feasible, effective way to address mental health in orthopedic care settings, but recent literature calls for more comparison data between digital interventions and other treatment arms. […]

22. Pathogen and Size Characterization of Aerosols Produced during Aerosol-generating Procedures in COVID-19 Positive Patient Intensive Care Units

Introduction: Airborne transmission of SARS-CoV-2 is thought to be greatest during aerosol-generating procedures (AGP) in the hospital. The true risk posed by AGPs is not well understood. Methods: Aerosol capture and real-time particle size characterization were performed in the medical intensive care unit (MICU) during mechanical ventilation, bi-level positive airway pressure (BiPAP) ventilation, high-flow nasal […]

23. Real-time Monitoring for Aerosol Generation in the Emergency Department using Low-cost PM Sensors during the COVID-19 Pandemic

Introduction: Emergency department (ED) healthcare personnel (HCP) provide acute medical care to the ill and injured. The day-to-day burden of aerosol exposure posed to ED HCP during patient care is not well understood, but remains a concern during the COVID-19 pandemic. Methods: Baseline air quality and aerosol characterization during routine ED patient care and emergent […]

24. An Integrated Machine Learning Model to Predict Respiratory Failure for COVID-19 Tested Patients in the Emergency Department:  A Silent Prospective Trial

Introduction: Acute hypoxemic respiratory failure (RF) is the hallmark symptom of COVID-19 infection that can lead to escalating oxygenation requirements and critical care utilization. Early identification of patients at risk for respiratory decompensation can facilitate timely resource deployment and mitigate care delays. To facilitate resource alignment with patient needs, a machine learning (ML) model designed […]

25. Development and Testing of a Mobile Phone Text Messaging Intervention Based on Patient Activation to Manage Fatigue for People with MS, SCI and Stroke

Introduction: Fatigue significantly impacts daily functioning for people with disabilities (PwD). Self-management programs targeting fatigue have shown promising effects for PwD. However, current satisfaction with fatigue self-management programs is low for PwD. Tailoring a self-management intervention based on patient activation may overcome this issue. This study aimed to describe the development of a mobile phone-based […]