Category: Early Stage

1. Surfactant Protein A Promotes Atherosclerosis through Mediating Macrophage Foam Cell Formation

Surfactant Protein A Promotes Atherosclerosis through Mediating Macrophage Foam Cell Formation

Introduction: Atherosclerosis (AT) is a progressive cardiovascular disease characterized by persistent inflammation and excessive cholesterol deposition within the artery wall and is the fundamental pathological process underlying coronary artery disease and stroke. Macrophage (MФ) foam cells play a central role in the pathogenesis of AT. Surfactant protein A (SPA) is a lipid-associating protein involved with […]

2. Improving CRISPR/Cas9 Editing Efficiency to Generate a GBA1 KO due to Pseudogene-induced Homology Directed Repair

Improving CRISPR/Cas9 Editing Efficiency to Generate a GBA1 KO due to Pseudogene-induced Homology Directed Repair

Introduction: The capability to translate research to the clinic is contingent upon the ability to study disease-causing mutations from patients in a cell type specific manner. This is most commonly accomplished through the introduction of these disease-causing mutations in induced pluripotent stem cells (iPSCs) and their subsequent differentiation. However, in certain cases, editing these genes […]

4. Digital Light 4D Printing of Bioresorbable Shape Memory Elastomers for Personalized Aneurysm Occlusion

Digital Light 4D Printing of Bioresorbable Shape Memory Elastomers for Personalized Aneurysm Occlusion

Introduction: Globally, aneurysms affect 2-5% and afflict millions in the U.S., presenting significant health threats due to their high rupture rate that can lead to death. Conventional aneurysm coil treatments grapple with problems such as adverse bodily reactions, biocompatibility issues, and a recurrence risk of about 20%, with complete occlusion failures in 10-15% of patients […]

5. Evaluating the Effect of an Ovine Acellular Dermal Matrix on Breast Implant Capsule Formation Using a Rodent Model

Evaluating the Effect of an Ovine Acellular Dermal Matrix on Breast Implant Capsule Formation Using a Rodent Model

Introduction: Implant-based breast augmentation is one of the most common cosmetic surgeries with over one million procedures performed to date using silicone implants. In 2022, 78% of breast reconstruction surgeries after mastectomy were also implant-based. Despite this popularity, over 10% of patients experience postoperative capsular contracture, potentially resulting in pain and distorted appearance. Current literature […]

6. Next Generation of Tissue Adhesive for Obliteration of Surgical Dead Space

Next Generation of Tissue Adhesive for Obliteration of Surgical Dead Space

Introduction: Many surgical procedures create large dead spaces prone to fluid accumulation, leading to hematomas and seromas. Drains are used to prevent these complications, but they often cause patient discomfort and have potential for infection. Our objective is to develop a biodegradable tissue adhesive with strong adhesion and biocompatibility to obliterate surgical dead space. Methods: […]