Hope Center Cores
Provides core resources and technical expertise to study mechanisms of neurodegeneration and neural repair, including Alafi Neuroimaging, Animal Surgery, DNA/RNA Purification, In Vivo Microdialysis, and Viral Vectors.
Cores offered by the Hope Center for Neurological Disorders provide investigators with resources and technical expertise to study mechanisms of neurodegeneration and repair. These include state of the art neuroimaging, surgical procedures for animal models, isolation of DNA and RNA from serum or saliva, microdialysis, and viral vector production.
- Alafi Neuroimaging Core: offers state-of-the-art equipment and software for imaging and scanning, and flow cytometry equipment. Contact Core Director, Michael Wong (wongm@neuro.wustl.edu).
- Animal Surgery Core: facilitates the development of new therapeutic strategies for nervous system disorders through expertise in animal surgery and/or protocol development. Contact Susie Grathwohl (sgrathwo@wustl.edu).
- DNA/RNA Purification Core: offers nucleic acid extraction from a variety of sources including fresh or frozen whole blood, buffy coat, saliva and frozen tissue and cell pellets. Large and small volume extractions are available. Contact Core Director, Carlos Cruchaga (cruchagac@wustl.edu).
- In vivo microdialysis: sampling of molecules within the extracellular tissue space (brain and muscle) to identify compounds for their ability to reduce brain interstitial fluid levels of Ab or other analytes. Contact Core Director, John Cirrito (cirritoj@neuro.wustl.edu).
- Viral Vectors Core: provides core support for investigators on the design and production of lentiviral and AAV vectors. Contact Core Director, Mingjie Li (lim@neuro.wustl.edu).
To learn more about Hope Center Core services, please contact the Hope Center, hopecenter@email.wustl.edu.