Introduction: Pregnant individuals with substance use disorders (SUD) are at higher risk of developing severe complications from COVID-19. Infants < 6 months are also at significant risk. Vaccination in perinatal individuals can help protect both mother and infant from severe outcomes; however, vaccine hesitancy is high. We evaluated COVID-19 vaccination rates among postpartum patients with […]
Introduction: Multiple sclerosis (MS) causes central nervous system lesions that alter neural communication between the brain and the spinal motoneurons that activate muscles. These voluntary motor commands consist of three components that must be appropriately balanced for skilled motor control: excitation, inhibition, and neuromodulation. Disruption of this balance has harmful effects, evidenced by work in […]
Introduction: Assessment of comorbid cardiovascular disease can predict health outcomes and may risk-stratify patients for adverse events and death. Current methods used to estimate patient risk, such as the Charlson Comorbidity Index (CCI), are based on International Classification of Diseases (ICD) codes, which are a poor indicator of severity and complexity of comorbid disease. In […]
Introduction: Burnout in medical trainees significantly increases their risk of suicidal ideation, and trainees are often reluctant to seek mental health care. Digital mindfulness and cognitive behavioral therapy (CBT) principles are evidence-based preventative strategies for reducing burnout and increasing professional satisfaction. We are conducting a randomized pilot study to assess whether digital interventions for CBT-based […]
Introduction: Dissemination and implementation (D&I) research, crucial in translating evidence into practice, is yet to be included as a separate study design category for ethical consideration. Researchers are asking relevant questions about how current ethical standards can be applied to D&I trials. The responsible conduct of D&I research requires an adaptation of existing bioethical frameworks […]
Introduction: Delaying pregnancy allows people with opioid use disorder (OUD) to choose when they are ready to continue their families. We aim to address the lack of characterization of postpartum contraceptive uptake among people with OUD compared to people without OUD. Methods: Analyses used 73,811 pregnancy episodes among 61,221 people (2016-2021) from the St. Louis […]
Introduction: A polypill containing all four classes of guideline-directed medical therapy (GDMT) for heart failure with reduced ejection (HFrEF) has been proposed to change the heart failure treatment paradigm. The acceptability, appropriateness, and feasibility of a HFrEF polypill-based strategy is unknown. The purpose of this study was to elicit patients’ and providers’ priorities in the […]
Introduction: Accurate prediction of Intensive Care Unit (ICU) patients’ mortality is crucial for healthcare professionals to make informed decisions, ultimately improving patient outcomes. However, ICU data are collected irregularly at different time points; therefore, these data are oftentimes incomplete and heterogeneous, hindering the performance of model-based statistical methods. This study aimed to use artificial intelligence […]
Introduction: In an increasingly competitive budgetary environment, we must be able to demonstrate the health and societal benefits of clinical and translational research. The Translational Science Benefits Model (TSBM) is a framework for evaluating the downstream health and social impact of research. The TSBM team created the online Translating for Impact Toolkit to help researchers […]
Introduction: There have been increased efforts to recognize the effects, or lack thereof, of scientific research on health equity. The Translational Science Benefits Model (TSBM) is a framework for evaluating the impact of research on health and society. The TSBM team is currently integrating equity into the TSBM framework. Methods: Adaptation of the TSBM involved […]