Brian Laidlaw, PhD
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Washington University in St. Louis (WU)
The Laidlaw lab investigates the development of immunological memory in disease states. Specifically, we are focused on understanding the transcriptional networks regulating the development and function of memory B cells. We use advanced mouse models, sequencing, and screening approaches to identify novels regulators of immune memory development and to determine the mechanisms by which these regulators function. The overall goal of this research is to facilitate the design of therapies that modulate the memory B cell response in order to drive a protective immune response. This work has important implications for the design of vaccines against highly mutable pathogens, as well as for the treatment of B cell driven diseases such as allergy and autoimmunity.