Washington University in St. Louis (WU)
Rosa-Molinar and his group apply to multi-scale multi-modal correlated volume resin microscopies, a systems engineering process concept known as “imaging chain” that includes determining provenance, searching, mining, processing, analyzing, displaying, storing, and managing datasets. The imaging chain enables the group to develop, refine, and use imaging tools and reagents to create image data sets required to unravel synapses’ three-dimensional nano-scale geometry and molecular diversity. They are particularly interested in electrical synapses (e.g., gap junctions), specifically “mixed synapses,” a poorly studied synapse that combines the features of both chemical and electrical synapses.