Guangyong Peng, MD, PhD

Professor of Otolaryngology

Washington University in St. Louis (WU)

My research seeks to understand how host immune systems respond to cancer cells and to develop effective vaccines against human cancers. A major research interest in my lab is focused on identifying the roles of different types of tumor-associated regulatory T cells (Tregs) in suppression of anti-tumor immunity. A second major area of interest in his lab involves the development of strategies to overcome tumor suppressive microenvironments induced by Tregs and tumor cells using Toll-like receptor (TLR) ligands and other immunomodulators. The combined knowledge resulting from these novel studies will potentially lead to the development of more effective vaccines and/or immunotherapies active against human cancers. In addition to his work towards development of cancer vaccines/immunotherapies, he also has begun to investigate the importance of Tregs during infections with chronic intracellular pathogens, such as Mycobacterium tuberculosis and virus.