Washington University in St. Louis (WU)
My research focuses on the advancement, characterization, and utilization of innovative radiopharmaceuticals for both diagnostic imaging and therapeutic applications in the realm of neurological disorders. Specifically, my current investigations delve into the causes, diagnosis, and potential treatment options for Alzheimer’s disease. A key focus is on comprehending the role and development of neuroinflammatory biomarkers associated with this condition. To achieve this, my study employs a diverse range of techniques including small molecular positron emission tomography to visualize neuroinflammation, high-content screening methods to examine synaptic loss, and in vivo and in vitro phage display-based screenings of peptides and antibodies. Additionally, I am engaged in the bioengineering of nanobodies to enhance neuroimaging capabilities and therapeutic potential. Through these multidisciplinary approaches, I aim to contribute to our understanding of Alzheimer’s disease pathogenesis and explore novel avenues for diagnosis and treatment.