Washington University in St. Louis (WU)
The commitment to understanding AD and other dementia pathophysiology remains at the center of my career goals. My career goal is to perform goal-oriented research using multiple approaches to have an in-depth understanding of the role of astroglia in neurobiology and neurodegenerative disorders with a view to finding the possible therapeutic target. The pathological significance of astrocytes in the etiology of Alzheimer’s disease (AD) and other dementia has been linked to disease onset and development. However, their in-depth pathophysiology across different brain regions has not been entirely elucidated. My interest is to use multiple approaches such as computational prediction, genetic manipulation, molecular biology, biochemical, and immunohistochemistry techniques to comprehensively characterize astrocyte identities, regulation, and manipulation to elucidate their roles in neurodegenerative diseases and to develop novel therapy against AD.