Saint Louis University (SLU)
Dr. Garg’s Musculoskeletal Tissue Engineering Lab at SLU focuses on developing novel regenerative and rehabilitative therapies for the treatment of traumatic muscle injuries. The regenerative approach we are pursuing involves using multifunctional biomaterials that enhance muscle regeneration and function. These biomaterials are composed of extracellular matrix proteins that are chemically cross-linked and processed in the form of biosponges, hydrogels, or micro- or nano-particles for various applications. Not only do these biomaterials provide mechanical support, but they can also deliver growth factors, pharmaceuticals, stem cells, and exosomes to targeted areas, suppress immune responses, and act as a substrate for host cell infiltration and proliferation. Our rehabilitative strategy involves neuromuscular electrical stimulation-mediated strength training to improve muscle mass, size, and torque. Ongoing research investigates the synergistic effect of combining regenerative and rehabilitative strategies to optimize their efficacy.