Mathieu Garand, PhD

Washington University in St. Louis (WU)

In the lab, we perform basic and clinical research to explore the causes of congenital heart diseases. We test hypotheses by analyzing specimens from women with pregnancies affected by CHD, and pediatric patient samples, as well as by studying offspring in animal models exposed to infections in early gestation. To drive discoveries, we used advanced experimental and analytical tools such as phage immunoprecipitation coupled with next-generation sequencing technology. Current topics are: Prevalence of human Pegivirus in subjects with SARS-CoV-2 infection; Investigating Enterovirus and the stool microbiome in pregnant women with and without diabetes; Perinatal viral infection effects on the development of heart defects; Infectious diseases or immune-related disorders following a surgical procedure such as valve repair or heart transplant.