Matthew R. Rosengart, MD, MPH

Washington University in St. Louis (WU)

My lab has a long-standing record of examining the role of immunity in the systemic response to injury and infection, with particular expertise in phagocyte biology, calcium homeostasis and signaling, mitochondrial dynamics and function, and circadian biology, using clinically relevant models of sepsis and trauma. My collective training in the clinical, biological, and epidemiological sciences has provided me particular expertise in the conduct of translational studies, particularly those of a T1 nature. By combining diverse strategies of molecular and cellular biology, clinical analytics and bioinformatics, network analysis and mathematical modeling we have contributed substantially to understanding the biology of the inflammatory states of sepsis, ischemia and shock. Although my expertise is in innate immune activation signals, I also have published experience in the response of parenchymal cells, such as the kidney and liver, to septic and ischemic insults. I am particularly interested in novel mechanisms, strategies and therapeutics to improve the outcomes of sepsis and shock.